Thứ Bảy, 5 tháng 8, 2017

Youtube daily US Aug 5 2017

Natasha: Today we are doing a tutorial on these looks right here. Inspired by these shirts by the one and only Nathan Zed.

Meghal: We love Nathan Zed's content and his comedy but what we really love is that he came out with merch that wasn't like saying his name on it.

M: And it's very well designed and we like these shirts regardless that he made them or not.

M: Yeah, we were very excited for someone to come out with merch that wasn't like their name plastered on something.

M: Hope you enjoy today's get ready with us!

M: I already have some eyeshadow primer on!

N: Now I'm going to put some eye primer on.

M: I'm taking this really light kind of brown beige color from the Sonia Kashuk palette. It's matte.

M: Then I'm just running it in my crease to kind of set it.

N: I'm going to put Makeup Geek's Bitten all over my lid.

N: I'm doing eyeshadow first because there will be some fallout.

N: I'm bringing it above my crease as well.

M: Now I'm taking the Sigma short shader brush. It's the E20 and the color Love Plus from Sugarpill and I'm packing this all over my lid.

N: So some of you asked us where we get our recipes from when we cook. If you follow us on Instagram and watch our Instagram stories we post a lot about what we are cooking.

N: We get most of it from New York Times Cooking .com.

N: We've mentioned this in other videos before. They just have a lot of great chefs that write for them.

M: Melissa Clark! N: Yeah! N: And what's great is that the comments are really helpful too.

N: Because people will make adjustments. And usually comments on recipes don't really add anything and they're not helpful but

N: on New York Times you can like up vote them. So we often read those comments and find them really helpful.

M: And what's really great is that all the chefs on there are like legit established chefs.

M: And so a lot of the recipes on there are classic recipes.

M: We really like that because we really like learning the basics of different cuisine's and just trying new things out.

M: Especially stuff that we haven't tried before.

N: Then I'm gonna put the Colorpop Super Shock shadow in Static and I'm going to put it in the first half of my eye.

N: Like the inner corner. And I'm using the other side of this brush. So it's going to go like from shiny to matte.

M: If you follow any food blogs, like any baking Instagrams where they make the food really pretty and stuff and do different recipes

M: Sometimes they will use like really different ingredients that are really hard to access or some specialty liquor that some company has sent them

M: and it's like cauliflower and roasted eggplant tacos which isn't exactly a classic taco dish or something. N: Yeah it's almost as if

M: It's like mixing different stuff or just trying to make stuff look pretty.

N: Yeah, I was gonna say, I feel like the recipes are made just because they can photograph well and it's like attractive and more likeable on Instagram.

M: Yeah N: and it's not about like the actual taste haha

M: Or it's like trying so hard to be like healthy that like the original recipe what they're basing it off of say like a tomato pasta gets so far off from that.

M: So that's why we like cooking New York Times.

N: I like it better than like the Food Network recipes too because nowadays Food Network is kind of like a game show channel.

N: And it's not really about the food. It's just like competition shows and it's just more of like you watch the show because of their personality and the food looks good but

M: Like Bobby Flay. N: Yeah and like

N: our mom has actually tried a ton recipes like while- when we were growing up for years and half the time they don't turn out very good.

N: And honestly with the New York Times recipes, the success rate is so high on those recipes compared to anything else.

N: we've made before.

M: And it's really nice. The format of the website is really helpful and they have like cooking guides so they'll be like Top 10

M: corn recipes for this summer so you can just look through that and also there's a lot of

M: great vegetarian recipes. N: Yeah M: and it's recipes that aren't trying to be vegetarian they're just

M: happen to be vegetarian. Same with like vegan if you want vegan options too.

N: If a recipe does have meat in it or some sort of meat broth people will comment and say what they did to make some alternatives to the recipe to make it vegetarian or vegan.

M: The one main and big criticism that we have of this website is that every once in awhile they like try and do like an Asian

M: cuisine or something that is definitely not native to the chef's cooking background and it's just not as good.

M: Its better for those specific cuisines like Asian cuisines specifically to just find Asian cooks instead of going on cooking New York Times because they're best at kind of like European Mediterranean.

N: Basically don't use that website for any type of Asian food. M: Or even like Mexican food too. N: Yeah.

N: It's like French, American, M: Italian, and Mediterranean. N: Italian, and Mediterranean.

N: For recipes that are from Chinese recipes, Japanese recipes, Korean Recipes, M: Thai recipes. N: Thai Recipes. W e find those respective chefs on youtube

N: like Thai chefs and follow their food blogs and their videos because it's like so much more helpful and a lot more traditional than some I don't know

M: Watered down version. N: Yeah, some watered down version of Soba Noodles.

M: So I'm taking a small fluffy brush and just blending out the red into my crease.

N: And then I'm taking white eyeliner from Wet N' Wild and lining my lid.

M: I'm also bringing the shadow out a little bit.

N: Meg and I actually have a food blog.

N: Before we moved to New York we took a year off and lived at our parents' house.

N: After we graduated from college and that's when our mom taught us how to cook.

N: So we started documenting that and posting the recipes.

M: She taught us how to cook Indian food. South Asian dishes.

N: Definitely haven't posted on there in awhile just because it hasn't really been a priority and it's very difficult because

N: there's a lot of translating going on and

N: Basically mastering that learning curve has been pretty difficult so we very rarely post recipes but it's something that we work on as an ongoing project.

M: When it comes to Indian recipes, our mom and grandma are the go-to people for that haha. N: Yeah.

M: So I'm taking this shader brush again and packing on some of the red shadow that got blended away.

M: Now I'm taking a clean E40 and just blending out this crease a little bit more.

M: I'm always shocked that I don't get a bunch of comments on my videos saying that I don't know how to blend eyeshadow because I'm very self-conscious about it for some reason.

N: You are?

M: I don't know. Self-conscious is a strong word. I'm just not confident in my blending abilities.

N: Meg and I both actually want to do videos on recipes and like cooking vlogs but I think people forget how much harder it is to vlog.

M: I think I would definitely start doing cooking vlogs and just what I make during the week because everyone really likes us when we cook on Instagram

M: because we are always showing the recipes we cook but it's easy to do that on my phone and Insta-stories opposed to planning a video and everything but if we eventually get like a

M: something thats a really good vlogging camera I could see us doing that. N: Yeah.

M: I have finished the red shadow. Now I'm going to go ahead and do a black wing and I'm keeping it on the outer half of my eye.

M: And I'm also going to bring the wing more straight out opposed to like a wing that kind of flicks up.

N: Someone else asked us what our favorites are not beauty related.

N: I actually have been going through a bunch of artists on Instagram like illustration artists because at my job we are looking to work with a new set of artists.

N: I found a bunch of people that I really like. So I'll link some of them below.

N: I personally tried to find a lot of people of color because obviously they are often under represented.

M: So when I look straight forward you can see how the wing goes straight out but when I look down, the shape changes.

M: So you kind of have to go back and forth with looking forward and looking down to try and make the wing as smooth as possible.

M: And as I bring the liner in, I make sure it's very thin.

M: I've been really enjoying all the San Diego Comic Con content thats been coming out. Especially Lupita dressing up as Pink Ranger and dancing around the convention floor.

N: I'm just blending out the eyeshadow now.

M: We watched the show Legion on FX and it's soo good!

M: We keep talking about how it's like what art school kids what art school kids kind of want their collage montage videos to look like and

M: Legion does it very effectively without being too try hard.

N: The other thing that's very specific to legion is they do a lot of like flashbacks and other dimension type of filming

N: because you're going in and out of one of the character's head and like between memories

N: and the type of filming of making everything like surreal and very weird is relevant to depicting this guy's power.

N: Whereas other times when film students try and do all those special effects it's just not relevant to the content or storyline.

M: I messed up this wing so I have to re-do it. I brought it out like an entire centimeter.

N: Like I said, one of you asked us what our favorites are outside of beauty and this doesn't really have to do about favorites but it does about beauty so sorry.

N: So people ask us to try out different products and Meg and I don't get paid to do youtube. We have no sponsorship and we don't have management or anything.

N: So we don't have like a surplus of spending money for makeup.

N: Like when we buy stuff, we are very particular but I also feel like I don't care to buy anything anymore because

N: I don't think companies are doing a very good job with their launches. Now it's like every company is doing liquid lipsticks or companies are just

N: releasing stuff so frequently that you can't keep up or like the quality isn't as good.

M: Now I'm going to tightline with this black liner. We got this from By Terry on Octoly. Right as you're saying we don't get like a bunch of products.

M: The only place we don't like purchase ourselves are from Octoly but that's a very small amount. N: I mean in retrospect to everything we choose what we want sent to us and that's maybe one or two things a month.

M: One of the things we got is this black liner from Octoly and this is just like any other kind of gel eyeliner. It's nothing extraordinary so you don't need to fork out money for the By Terry version.

M: And it's like the exact same packaging as I think the Milani one and the Urban Decay 24/7.

N: I'm gonna do my brows which y'all have seen us do like 600 times. Brush them up first and then lightly fill them in.

N: My eyes look really funny without liner and mascara.

M: Yeah, the white also gets on your um, lashes.

N: Yeah.

M: Next I'm going to take this By Terry eyeshadow stick. So we've talked about these eyeshadow sticks before. We also got this from Octoly.

M: And the other ones that we've gotten have been great but for some reason this mint color isn't the best. It doesn't layer up nicely.

M: But I'm gonna smoke this on my lower lash line.

N: Random topic but if you haven't noticed, Meg and I caption all of our videos.

N: I noticed Youtube really stepped up their captioning game. It can really detect what you're saying so when you go and edit the automatic captions it takes

N: literally a third of the time opposed to typing out your own ones. But it's one of those things where it's so great but also really creepy that there's a program that captions really well.

M: Oh my gosh, if anyone has the time and speaks another language, feel free to add captions in a different language on any of our videos. That would be the coolest thing.

M: If I spoke Spanish or Telugu fluently I'd probably would do that but I don't.

M: Disappointment. Okay so I'm wiping off red shadow on the shader brush I was using earlier.

M: I always wipe shadow on the back of my hands if you're ever wondering. Look at that. It looks so pretty.

M: Next I'm taking the color Emerald from Anastasia and smoking this over the mint.

N: Now I'm just going to tight line with the By Terry pencil.

N: Some on the water line as well.

M: I'm taking this By Terry eyeshadow stick and using this as an inner corner highlight.

M: Now I'm taking an angled brush and going back in with Emerald and pulling out the green underneath the black liner. I feel like this

M: look can look very Christmassy or very Poison Ivy which I'm all down for looking like Poison Ivy.

M: I don't feel like looking like the holidays right now.

N: I'm just gonna put some mascara on.

M: Taking some eyeshadow on this brush and spraying it so I can get more of an opaque color.

N: Whats really cool about if you have white eyeliner and then you put mascara on. It really makes your eyelashes stand out because your eyelashes are pretty much going against a white background.

N: So there's a lot of contrast and it's very like fluttery and it can also look creepy but you know, all depends.

N: This why I never understand when people do like a really complicated eyeshadow look but then they put on like huge lashes and it just covers the eyeshadow and what is the point.

M: Sad.

M: All that blending for nothing.

N: Meghal constantly reads comics which is great. At night when Meg's reading them about every 10 minutes I hear her cackle from her room. I can safely assume it's because one of the comics.

M: She's right. I've also been watching the batman animated series because I'm working through all the D.C. animated content.

M: That's also great.

M: These "get ready with mes" always show how much faster Natasha is at her makeup.

M: I'm so slow.

N: Yeah but I think your makeup looks a lot more precise than mine.

N: Your mascara definitely always looks better.

N: Oh, you know what one of my favorites is, those sandals we just got.

M: Oh yeah!

N: Meg and I both have relatively large feet for our height. Not only that but they're wide and flat.

N: The opposite of traditional women's shoes. I found out that Sam Edelman shoes fit better and they're higher quality but they're not outrageously expensive.

N: when it's on sale. Lots of like the shoes, even though it's like form fitting kind of will stretch a little bit so it works really well for our feet and we found a pair of sandals that we really like.

M: These! They were sitting right next to us.

M: Obviously just doing my brows. Just filling them in.

N: I'm going to put some foundation on.

M: See I haven't even done my mascara yet. You're so much faster.

N: You take much longer to do mascara too than me.

M: Just putting some brow gel on.

N: Have any of you guys use the Smashbox foundation? It's like their water foundation.

M: Or any of the Stila foundations? Because both Smashbox and Stila just went cruelty free. Smashbox does have a parent company but still.

N: Better than Nars who is not cruelty free anymore.

M: Sad. N: It's just so annoying because they have the best undertones.

M: I'm just finishing up putting my mascara on. Did most of it off camera.

N: I just touched up my eyeliner and eyeshadow a little bit.

M: I'm gonna put a little bit more black liner on because usually it wears down a little bit and I usually put one layer on and go back in with another because it will last longer that way.

N: I'm just putting some concealer on. I wanted to mention on the topic of not wanting to buy any makeup really from all the launches

N: I think one of the main issues is that the actual color choice. The colors just aren't that interesting and they're very just the same.

M: I don't know. N: Yeah, they're all the same. Everyone has come out with like 6 million different colors of mauve lipstick.

N: I feel like companies are more concerned with "staying relevant" and constantly launching stuff than actually creating good stuff.

M: Or they're just doing really trendy or gimicky stuff. I'm going in with some concealer. Blending out my concealer.

M: Blending out concealer now with a setting brush.

N: I'm just putting some of this contour powder on.

M: Now I'm going in with some tinted moisturizer.

M: You know what I've been loving, not wearing makeup!

M: New York summers are hot. The thing is Michigan summers are hot too but we have like clean air. At least cleaner than here.

M: And now I'm going in with some setting powder.

N: I'm just blending out little bits and pieces that I think need to be blended out more.

M: Now I'm going to just put a little bit of contour slash bronzer.

N: For lips I'm going to put Glossier's Leo on.

M: For highlighter I'm just putting some of Haloscope on in Moonstone.

M: I really love this highlighter. Of course just tapping it in otherwise it disturbs the makeup on underneath.

N: I'm going to put a little bit of this Nars blush in Sangria on.

N: It's literally the same color as this shirt. M: Oh thats perfect.

M: For my lips I'm also going to put Leo on. This is such an intense makeup look for a Sunday.

N: And I am done before you. M: As always.

M: I did the same lip combo in my last video. I'm putting a little bit of this lip gloss on on the color Tantalizing Honey.

N: That's it right? M: Yup.

N: Haha looks great Meg!

M: And these are our finished makeup looks. I hoped you like this get ready with me tutorial!

N: I hope you like this get ready with us tutorial!

M: No, it's just me. I'm the only one in this video. You don't exist. N: You right. M: hahaha

For more infomation >> Good Enough | Get Ready With Us - Duration: 15:26.

-------------------------------------------

Leaning utility poles being fixed along US 79 in Round Rock - Duration: 0:32.

For more infomation >> Leaning utility poles being fixed along US 79 in Round Rock - Duration: 0:32.

-------------------------------------------

Extreme Weather Hits All Corners Of The U.S. | NBC Nightly News - Duration: 1:45.

For more infomation >> Extreme Weather Hits All Corners Of The U.S. | NBC Nightly News - Duration: 1:45.

-------------------------------------------

After years of slow recovery, U.S. economy boasts solid gains - Duration: 5:53.

JUDY WOODRUFF: July was the second straight month of solid job gains in the United States.

The Labor Department says employers added 209,000 jobs last month.

That dropped the unemployment rate down to 4.3 percent, tying a 16-year-low.

The good report pushed stocks higher on Wall Street.

The Dow Jones industrial average gained 66 points to close at 22092.

That is its eighth straight record high.

Let's get an assessment about the job market and the stock market and what it means for

millions of Americans.

I'm joined by Mark Vitner, managing director and senior economist at Wells Fargo.

Mark Vitner, welcome to the program.

So, just how good a jobs report is this?

MARK VITNER, Senior Economist, Wells Fargo: Well, it's a pretty solid report, pretty much

top to bottom; 209,000 jobs exceeded what folks were looking for.

We had a small upward revision of the prior data.

And we saw that a very wide majority of industries added jobs.

Over 60 percent of the industries that make up the employment survey added jobs during

the month of July.

JUDY WOODRUFF: Why is it doing so well?

What's the driver behind this?

MARK VITNER: Well, I think that, after eight years of economic growth, things are finally

beginning to broaden a little bit.

Previously, most of the growth that we saw in the economy, most of the improvement was

coming from either the tech sector or the energy sector.

Then energy faltered a little bit, oil prices came down, and things slowed a little bit

in 2015 and 2016.

In this past year, we have seen that global growth picked up, oil prices have rebounded

a little bit.

And so, really, for the first time since the recession, it seems like we're firing on all

cylinders.

The strength we have in the economy is broadening.

It's reaching not only more industries, but more parts of the country.

JUDY WOODRUFF: So, when you say it's firing on all cylinders, you mean literally everywhere

in every kind of industry?

MARK VITNER: Well, I wish it was literally everywhere, but it's in more places than it

used to be.

And there are a lot of places.

And you look within a state.

You go to Tennessee, for example, and Nashville's been booming for a long time, but Memphis

really hasn't been doing that well.

Memphis is finally beginning to see some stronger economic growth.

And some of that is that we have had so much growth in a handful of areas, that their unemployment

rates have gotten low enough that companies are now searching for other places where they

can find workers, find office space, find industrial space.

And so the strength to have the economy seems to be reaching more parts of the country.

JUDY WOODRUFF: So now let's talk about the stock market.

It also seems to be roaring.

And we said a minute ago apparently it eighth straight record.

What's going on there?

MARK VITNER: Well, recently, a lot of that has been in the tech sector, where we have

had very good earnings.

And the stock market and the economy are somewhat reflecting the same thing.

We had a slowdown in the global economy in 2015 and 2016, and the U.S. economy was outgrowing

the rest of the world, and the dollar shot up in value.

That made it very tough for companies to boost their profit margins.

Within the last year, we have seen that global demand picked up.

And more than half of the earnings of the Fortune -- of the S&P 500 come from overseas.

And that stronger growth is translating into stronger profits, and that's what's taken

the market up.

JUDY WOODRUFF: And we see that wages are finally beginning to pick up a little as well.

But what about -- Mark Vitner, what about ordinary Americans?

You still get the sense that many people say they don't feel they're part of this great

boom, this recovery that's taking place.

MARK VITNER: Well, America is a vast country, and you have got people of all walks of life.

And so it's not surprising that a lot of people, and I would say most people, aren't really

tied into the stock market, at least not directly.

But I can tell you that companies are more likely to add workers and boost salaries and

expand their operations when stock prices are going up than when they're going down.

When the stock market is going down and we're talking about eight straight losing sessions,

actually longer than that, when we have a pullback that persists, there is a lot of

pressure on corporate managers to find cost savings.

And that's when -- so a weaker stock market may show up to ordinary Americans a lot more

directly than a stronger one shows up.

But ordinary Americans do benefit from a stronger stock market.

Whether they do so directly, maybe not -- even if they don't do so directly, they do benefit

indirectly.

JUDY WOODRUFF: And it sounds as if you're saying, if they haven't felt it already, maybe

they will feel it soon.

MARK VITNER: Well, I would certainly hope so.

I think that the improvement in the stock market -- when the stock market goes up for

odd reasons, then it probably doesn't mean that much.

But when it goes up because the economy is improving, and we're seeing a broadening in

the strength of the economy and earnings have improved, that's something that should benefit

everyone.

JUDY WOODRUFF: Final question.

President Trump has said on a number of occasions that he deserves a lot of credit for this.

How much does any president -- how much credit does any president deserve when the economy

booms?

MARK VITNER: My philosophy has always been give them credit when it's good and blame

when it's bad, because they get all the blame when it goes bad.

But President Trump's policies are pro-growth.

The problem is, is that none of those policies have really been enacted.

The one area where the president has made progress has been lessening the load of regulation,

and we see that in some of our surveys of small business, where the number of businesses

that say that their number one problem is regulation has fallen substantially over the

last six months.

And I think that has contributed to a little bit of the pickup that we're seeing in business-fixed

investment.

JUDY WOODRUFF: Mark Vitner of Wells Fargo, it's nice to have a good report on the economy

for a change.

Thank you.

MARK VITNER: Glad we could help.

For more infomation >> After years of slow recovery, U.S. economy boasts solid gains - Duration: 5:53.

-------------------------------------------

Saudi Arabia Asks US Judge to Dismiss Lawsuit Over 9/11 Attacks - Duration: 0:57.

For more infomation >> Saudi Arabia Asks US Judge to Dismiss Lawsuit Over 9/11 Attacks - Duration: 0:57.

-------------------------------------------

Three missing after US military helicopter 'mishap' off Australian coast - Duration: 4:19.

Three missing after US military helicopter 'mishap' off Australian coast

Three missing after US military helicopter mishap off Australian coast      .   An MV-22 Osprey pictured at an RAAF Base in Townsville.

A search is under way after a US military helicopter crashed off the coast of Queensland, Australia. The aircraft, an MV-22 Osprey, crashed at Shoalwater Bay near Rockhampton on Saturday afternoon.

There were reportedly 26 people on board when the crash unfolded as the aircraft tried to land, with three still unaccounted for.

Other military aircraft and ships have been sent to the area, where they are combing the water for any sign of the missing service members. In a statement, the US Marine Corps Public Affairs Office said there had been a mishap.

The United States Marine Corps confirms there is an active search and rescue mission ongoing for service members involved in an MV-22 mishap off the east coast of Australia, the statement said.

Ships, small boats and aircraft from the 31st Marine Expeditionary Unit and Bonhomme Richard Expeditionary Strike Group are conducting the search and rescue operations. We will provide more details as they become available.

Australian Defence Minister Marise Payne said she had been in contact with her US counterpart, and confirmed no members of the Australian Defence Force were on board.

I have been advised of an incident involving a United States Marine Corps MV-22 Osprey helicopter off the coast of Shoalwater Bay today, Payne said on Saturday night.

I can confirm no Australian Defence Force personnel were on board the aircraft. The United States are leading the search and recovery effort, she said.

I have briefed Prime Minister Turnbull and spoken with Secretary (of Defence James) Mattis this evening to offer Australias support in any way that can be of assistance. Our thoughts are with the crew and families affected.

US forces were in Australia for Talisman Saber, a joint military exercise involving 33,000 US and Australian troops which is held each two years. The combat readiness training, which was expected to end in late July, was based at Shoalwater Bay Training Area, near Rockhampton.

MV-22s have been involved in several serious crashes, some of them fatal, in the 10 years they have been used by the US military.

In January this year, an MV-22 had a hard landing during a raid in Yemen, injuring three soldiers on board. The $75 million aircraft was then destroyed by an air strike.

In December 2016, the US grounded its fleet of the aircraft in Japan, after one crash-landed off Okinawa. That incident was also described as a mishap.

For more infomation >> Three missing after US military helicopter 'mishap' off Australian coast - Duration: 4:19.

-------------------------------------------

Vagina tattoos R Us: Celebs expose intimate ink in sweeping trend - Duration: 3:35.

Vagina tattoos R Us: Celebs expose intimate ink in sweeping trend

They all have tattoos in a seriously intimate area, and theyre not the only ones. A new trend is sweeping the world of showbiz, much like the boob-cupping fad, and the up skirt selfie.

And this time, its all about vagina tattoos. Yup, this is now a thing. The stars have decided to take their love of ink and couple it with their penchant for flesh-flashing to sizzling effect.

NEW CELEB TREND: Maitland Ward is a big fan of the vagina tattoo.

First up to display their love of the new trend is the legendary Britney Spears. The aforementioned starlet is often taking to social media to tease fans with seriously sexy snaps, as well as workout videos and general day-to-day life.

However, one of her more raunchy snaps saw the blonde flaunting two tattoos on her pelvis.

Wearing a pair of blue jogging bottoms, the songstress tugged down at the waistband to expose a cross design on one side, alongside a star on the other.

NOT THAT INNOCENT: Britney Spears also had a cheeky design on her bod.

INSTAGRAM CELEBRITY BIG BROTHER STAR: We might see more of Jemma Lucys design soon.

Britneys work is on the smaller side, whereas Celebrity Big Brother newcomer Jemma Lucys work is much more extensive. The raven-haired beauty has an angel-wing inking across the lower half of her body, which she often exposes on Instagram.

Jem isnt the only one with this type of design, as lads mag sensation Jodie Marsh has a similar design across her nether regions. Whenever Jodie takes a trip abroad, shes keen to flaunt her toned figure in teeny bikinis.

BOOBS, OR SOME INTIMATE INK?: Jodie Marsh has both.

That said, the bodybuilder doesnt need a holiday as an excuse to flash the flesh, as her social media is littered with raunchy snaps showing off her biker gal tat. And we couldnt make this list without mentioning Maitland Ward.

The professional flesh-flasher – known for her roles in Boy Meets World and White Chicks – proudly showcases her intimate ink whenever the opportunity presents itself.

REALITY BABE: Sallie Axl is a tattooed goddess.

In fact, the flame-haired beauty doesnt appear to be able to go longer than a few weeks without getting her explicit ink out. The starlet has had a teeny four leaf clover etched onto her privates and coloured in green.

Judging by the likes its racking up, it really is a good luck charm.

For more infomation >> Vagina tattoos R Us: Celebs expose intimate ink in sweeping trend - Duration: 3:35.

-------------------------------------------

Life threw us a curveball! - Duration: 1:32.

Hey everybody.

This is Bailey.

I know, I know, this looks really different, doesn't it?

[Uh] {short laugh}

Unfortunately, I did not make any new videos

Because

Well {giggles}

Life.

You know how it is.

They threw us a curveball.

See here?

What happened is…

Well, we got invaders.

We either got bedbugs or fleas.

We're not sure.

{short laugh}

So I've been busy killing off the invaders.

So…

But never fear, I made a collab video with Rogan Shannon.

And I will attach his link up here in this corner or down here in the description box.

So please do check it out.

And I promise, I pinkie promise that I'll make… post my new video by next Saturday.

It's just.

Right now.

Life kicked us in the teeth and we're trying to recover from it.

Anyway.

I hope I see you next Saturday and.

Wish us luck! {laugh}

Bye!

For more infomation >> Life threw us a curveball! - Duration: 1:32.

-------------------------------------------

The U.S. Military vs. Russia and China: Who Would Win World War 3? - Duration: 4:01.

The U.S. Military vs. Russia and China: Who Would Win World War 3?

U.S. alliance structure in the Pacific differs dramatically from that of Europe. Notwithstanding concern over the commitment of specific U.S. allies in Europe, the United States has no reason to fight Russia apart from maintaining the integrity of the NATO alliance.

If the United States fights, then Germany, France, Poland and the United Kingdom will follow.

In most conventional scenarios, even the European allies alone would give NATO a tremendous medium term advantage over the Russians; Russia might take parts of the Baltics, but it would suffer heavily under NATO airpower, and likely couldn't hold stolen territory for long.

In this context, the USN and USAF would largely play support and coordinative roles, giving the NATO allies the advantage they needed to soundly defeat the Russians.

nuclear force would provide insurance against a Russian decision to employ tactical or strategic nuclear weapons. The United States discarded its oft-misunderstood "two war" doctrine, intended as a template for providing the means to fight two regional wars simultaneously, late last decade.

Designed to deter North Korea from launching a war while the United States was involved in fighting against Iran or Iraq (or vice versa,) the idea helped give form to the Department of Defense's procurement, logistical and basing strategies in the post–Cold War, when the United States no longer needed to face down the Soviet threat.

The United States backed away from the doctrine because of changes in the international system, including the rising power of China and the proliferation of highly effective terrorist networks.

But what if the United States had to fight two wars today, and not against states like North Korea and Iran? What if China and Russia sufficiently coordinated with one another to engage in simultaneous hostilities in the Pacific and in Europe?.

Could Beijing and Moscow coordinate a pair of crises that would drive two separate U.S. military responses? Maybe, but probably not.

Each country has its own goals, and works on its own timeline. More likely, one of the two would opportunistically take advantage of an existing crisis to further its regional claims.

For example, Moscow might well decide to push the Baltic States if the United States became involved in a major skirmish in the South China Sea. In any case, the war would start on the initiative of either Moscow or Beijing.

The United States enjoys the benefits of the status quo in both areas, and generally (at least where great powers are concerned) prefers to use diplomatic and economic means to pursue its political ends.

might create the conditions for war, Russia or China would pull the trigger. Flexibility. On the upside, only some of the requirements for fighting in Europe and the Pacific overlap. As was the case in World War II, the U.S.

Army would bear the brunt of defending Europe, while the Navy would concentrate on the Pacific. Air Force (USAF) would play a supporting role in both theaters.

Russia lacks the ability to fight NATO in the North Atlantic, and probably has no political interest in trying.

This means that while the United States and its NATO allies can allocate some resources to threatening Russia's maritime space (and providing insurance against a Russian naval sortie,) the U.S. Navy (USN) can concentrate its forces in the Pacific.

Depending on the length of the conflict and the degree of warning provided, the United States could transport considerable U.S. Army assets to Europe to assist with any serious fighting.

The bulk of American carriers, submarines and surface vessels would concentrate in the Pacific and the Indian Oceans, fighting directly against China's A2/AD system and sitting astride China's maritime transit lanes.

Long range aviation, including stealth bombers and similar assets, would operate in both theaters as needed. military would be under strong pressure to deliver decisive victory in at least one theater as quickly as possible.

This might push the United States to lean heavily in one direction with air, space and cyber assets, hoping to achieve a strategic and political victory that would allow the remainder of its weight to shift to the other theater.

Given the strength of U.S. allies in Europe, the United States might initially focus on the conflict in the Pacific.

For more infomation >> The U.S. Military vs. Russia and China: Who Would Win World War 3? - Duration: 4:01.

-------------------------------------------

Schuld an Eiszeit zu Russland: Trump haut verbal auf US-Kongress ein - Duration: 6:00.

For more infomation >> Schuld an Eiszeit zu Russland: Trump haut verbal auf US-Kongress ein - Duration: 6:00.

-------------------------------------------

Wut auf neue US-Sanktionen: Iran droht mit "angemessener" Antwort - Duration: 5:40.

For more infomation >> Wut auf neue US-Sanktionen: Iran droht mit "angemessener" Antwort - Duration: 5:40.

-------------------------------------------

Animal Models of MPN - What Do They Teach Us? - Duration: 7:00.

Hi.

This is Dr. Rick Van Etten from the Chao Family Comprehensive Cancer Center at the University

of California, Irvine.

I'm going to talk about the clinical importance of mouse models of myeloproliferative neoplasms:

What do they teach us, with a focus on what the clinical utility of these models has been.

Again, let's talk first about chronic myeloid leukemia or CML.

These models have been very useful in several aspects in helping us to understand CML pathophysiology,

with implications for treatment of patients.

We all know that CML patients have different responses to tyrosine kinase inhibitor therapy,

and the reasons are largely unknown, but this mouse modeling study showed that one of the

things that influences the initial response to TKIs is the status of a protein called

BIM.

Now BIM is a pro-apoptotic protein, which triggers mitochondrial apoptosis.

On the left panel, you can see that mice that either are missing one or two copies of the

BIM gene have a greatly blunted response to the tyrosine kinase inhibitor imatinib, in

terms of the ability to induce cell death in CML cells.

In the subsequent study by the group from Singapore on the table on the right, you can

see that there is a polymorphism in the BIM gene that is particularly prevalent in East

Asian cohorts.

There is a very good correlation of initial response to imatinib, whether or not you carry

this BIM deletion polymorphism in a population.

Another great area of interest in chronic myeloid leukemia are strategies to eliminate

what we call the leukemic stem cells.

The B cells are postulated to be the cause of persistence of disease and a relapse of

disease when patients have their tyrosine kinase inhibitor therapy discontinued.

Mouse models have been very important in identifying pathways that regulate leukemia stem cell

survival and proliferation.

Among these are the Wnt/beta-catenin pathway, the Hedgehog/Smo pathway, a pathway involving

Alox5, which is a leukotriene metabolizing enzyme, and the PML gene, promyelocytic leukemia

gene, which is involved in nuclear bodies and regulation of stability.

As the consequence of these discoveries, there are numerous clinical trials of targeted therapies,

which are directed at these pathways.

The goal of these trials is to try to eliminate minimal residual disease in CML, leading to

permanent cure of the disease.

Now, these models have also been applied to the PH-negative model of myeloproliferative

neoplasms, and one of the most valuable things in the next slide has been helping us classify

the genetic mutations that we see in these MPNs and place them in different categories.

On the left side, I have shown what we would call "Phenotypic driver mutations" in these

diseases.

These include mutations in JAK2, MPL, and, more recently, calreticulin and LNK/CBL.

What I mean by a driver mutation is this is a mutation that is introduced into a hematopoietic

stem cell in a mouse.

It can recapitulate part, or all, of the myeloproliferative phenotype that we associate with the disease.

By contrast on the right, there's a group of genes that I call modifiers.

These include TET2, IDH1 and 2, DNA methyltransferase 3a, and others.

These genes, when they're reintroduced into mouse stem cells, do not recapitulate by and

large the MPN phenotype, but instead may have other phenotypes.

For instance, type 2 IDH1 and 2, and DNMT3-a, when introduced into mouse stem cells, all

increased stem cells self-renewal, but did not cause myeloproliferative phenotype.

Hence, they will be placed in a category known as modifiers.

Another thing where mouse models have been found to be useful is to try to answer the

question of genotype, phenotype correlation.

By that I mean the JAK2 V617F mutation is found in virtually every patient with polycythemia

vera, but can also be found in about half of patients with essential thrombocythemia

and myelofibrosis.

Why might that be?

There is persuasive evidence from mouse models that it is the mutant allele burden of JAK2

and its expression level that may influence the disease phenotype.

This is summarized on a figure from a review from Tony Green's lab, which shows that in

the various mouse models that express JAK2 V617F, at different levels you find either

an ET-like phenotype with predominantly elevated platelets, or a PV-like phenotype with predominant

elevation of the hematocrit.

I think mouse models have gone a long way toward explaining this clinical conundrum.

The other thing the mouse models have been good for, as I've mentioned, is showing the

difference between the driver and non-driver mutations.

As I've mentioned, mutations in TET2 and DNMT3a have been actually recently identified by

clonal analysis as preceding the driver mutations when they're required in the human disease.

Interestingly, the same mutations are often found as acquired mutations in elderly individuals

who have clonal hematopoiesis.

This fits perfectly with their ability to increase self-renewal of stem cells in the

mouse models.

To summarize what we have learned about the epigenetic regulators in MPN pathogenesis

is that mutations in these genes that encode epigenetic regulators are frequently found

as modifiers.

Many of these mutations as single lesions have very subtle effects on hematopoietic

stem cells self-renewal.

The molecular mechanisms are as yet unknown.

But importantly, although there's great interest in trying to target these lesions, most of

these mutations result in a decrease or loss of function, and hence, they may not be good

targets for therapy.

To summarize, a current model for the pathogenesis of PH-negative MPNs through mouse models is

that there may be a heterozygous mutation in JAK2, in calreticulin, or MPL as the initiating

mutation that may all have an ET-like phenotype.

With an increase in the JAK2 gene dosage, you may progress to polycythemia vera, and

then after acquisition of additional genetic or epigenetic processes, move on to myelofibrosis.

Clinically relevant questions remaining on the MPN pathogenesis: One is of what etiology

is so-called triple-negative MPN, lacking mutations in JAK2, MPL, or calreticulin?

There's a lot of interest in what the pathobiology of calreticulin mutant MPN is.

What treatment modalities can impact the natural history in the malignant clone in the MPNs?

Agents under investigation in mice and in humans include JAK2 inhibitors and interferon

alpha.

Then, lastly, can we therapeutically exploit the mutations and epigenetic regulators in

MPNs?

This completes the discussion of the clinical importance of mouse models of MPN, and I'd

like to thank you all for your attention.

For more infomation >> Animal Models of MPN - What Do They Teach Us? - Duration: 7:00.

-------------------------------------------

North Korea taunts the US over 'dirty' travel ban: 'Our door is ALWAYS open to Americans' - Duration: 3:09.

North Korea taunts the US over 'dirty' travel ban: 'Our door is ALWAYS open to Americans'

NORTH KOREA: Kim Jong-un taunted the US as he promised Americans are always welcome.

Kim Jong-un hit out over Donald Trump's decision to ban US citizens from travelling to the rogue state following the death of student Otto Warmbier. Pyongyang issued a sneering rebuttal to Washington as it branded the move a "dirty scheme".

North Korea said it continued to welcome US citizens, despite having been accused of beating and torturing Warmbier before his death in June.

Trump's travel ban comes as Kim urged the US to "surrender" as nuclear war talk continues to brew between the two nations.

US nationals will be barred from travelling to North Korea next month amid safety concerns. Warmbier was returned to the US in a vegetative state after being arrested and sentenced to hard labour for stealing a poster.

North Korean officials claim he contracted botulism, but his parents alleged he had been tortured.

OTTO WARMBIER: The US citizen died after being imprisoned in North Korea.

NUCLEAR WAR: North Korea continues to test ICBMs as it squares up to Washington.

The move is a dirty scheme aimed at limiting human exchanges to prevent US citizens from seeing North Korea as it is and a failure of its hostile policy," North Korea's foreign ministry said.

This reflects Washingtons view that it regards us as an enemy. The door is always open to all Americans who want to visit North Korea with good faith and see its real state.".

After the death of Warmbier, North Korea claimed it was the "biggest victim" and had been the subject of a "smear campaign". Tourists trips to the secretive nation are stringently managed and watched by officials from Pyongyang.

Photography is strictly controlled – but some tourists still manage to smuggle out images from North Korea. North Korea simulates missile attack on US in bizarre pop concert.

War fears continue to brew between Washington and Pyongyang over Kim's quest for nuclear weapons. North Korea launched a second successful ICBM test last month as it boasted its ability to strike the US.

Trump's advisor H.R McMaster urged Kim not to "sleep easily" as conflict looms in the Korean Peninsula.

Không có nhận xét nào:

Đăng nhận xét